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Christopher P F Redfern Selected Research

Fenretinide

4/2011Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition.
9/2010Targeting X-linked inhibitor of apoptosis protein to increase the efficacy of endoplasmic reticulum stress-induced apoptosis for melanoma therapy.
2/2010Regulation of endoplasmic reticulum stress-induced cell death by ATF4 in neuroectodermal tumor cells.
2/2009Combining the endoplasmic reticulum stress-inducing agents bortezomib and fenretinide as a novel therapeutic strategy for metastatic melanoma.
7/2008Increasing melanoma cell death using inhibitors of protein disulfide isomerases to abrogate survival responses to endoplasmic reticulum stress.
3/2007Role of Noxa in p53-independent fenretinide-induced apoptosis of neuroectodermal tumours.
10/2005The role of gangliosides in fenretinide-induced apoptosis of neuroblastoma.
6/2005Fenretinide: a p53-independent way to kill cancer cells.
4/2005p38MAPK-Dependent sensitivity of Ewing's sarcoma family of tumors to fenretinide-induced cell death.
12/2004Molecular mechanisms of fenretinide-induced apoptosis of neuroblastoma cells.
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Christopher P F Redfern Research Topics

Disease

26Neuroblastoma
02/2019 - 01/2002
13Neoplasms (Cancer)
01/2018 - 03/2002
8Melanoma (Melanoma, Malignant)
06/2015 - 03/2007
3Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
11/2021 - 08/2016
3Lung Neoplasms (Lung Cancer)
01/2018 - 03/2002
3Obesity
10/2008 - 01/2004
3Metabolic Syndrome (Dysmetabolic Syndrome X)
10/2008 - 05/2006
2Leukemia
03/2011 - 07/2002
2Cushing Syndrome
10/2008 - 05/2006
1Leukopenia
11/2021
1Neoplasm Metastasis (Metastasis)
08/2014
1Autoimmune Diseases (Autoimmune Disease)
10/2012
1Skin Neoplasms (Skin Cancer)
10/2012
1Neuroectodermal Tumors (Neuroectodermal Tumor)
02/2010
1Insulin Resistance
06/2008
1Residual Neoplasm
02/2007
1Abdominal Obesity
05/2006
1Glucocorticoid Receptor Deficiency
05/2006
1Ewing Sarcoma (Sarcoma, Ewing)
04/2005

Drug/Important Bio-Agent (IBA)

16FenretinideIBA
04/2011 - 09/2002
12Tretinoin (Retinoic Acid)FDA LinkGeneric
03/2013 - 01/2002
11RetinoidsIBA
10/2012 - 01/2002
5Messenger RNA (mRNA)IBA
11/2013 - 01/2002
5Bortezomib (Velcade)FDA Link
04/2011 - 07/2008
3DNA (Deoxyribonucleic Acid)IBA
11/2021 - 06/2005
3Proteins (Proteins, Gene)FDA Link
11/2013 - 11/2003
3Pharmaceutical PreparationsIBA
03/2013 - 02/2007
3Tetracycline (Achromycin)FDA LinkGeneric
01/2013 - 12/2003
3Retinoic Acid 4-Hydroxylase (CYP26B1)IBA
10/2011 - 09/2008
3Complementary DNA (cDNA)IBA
03/2011 - 11/2003
3GlucocorticoidsIBA
10/2008 - 01/2004
3retinamideIBA
06/2005 - 11/2003
22-mercaptopurineIBA
11/2021 - 07/2002
2NucleotidesIBA
11/2021 - 06/2008
2Azathioprine (Imuran)FDA LinkGeneric
01/2017 - 08/2016
2Celecoxib (Celebrex)FDA Link
08/2014 - 02/2007
2Biological ProductsIBA
10/2011 - 04/2011
2Thioguanine (Tioguanine)FDA Link
03/2011 - 07/2002
2Mercaptopurine (6 Mercaptopurine)FDA LinkGeneric
03/2011 - 07/2002
2CaspasesIBA
09/2010 - 12/2004
2Glucocorticoid Receptors (Glucocorticoid Receptor)IBA
06/2008 - 05/2006
2Caffeine (No Doz)FDA LinkGeneric
03/2007 - 08/2005
2EnzymesIBA
02/2007 - 09/2004
2Sphingomyelin Phosphodiesterase (Sphingomyelinase)IBA
10/2005 - 09/2004
2Arachidonate 12-Lipoxygenase (12 Lipoxygenase)IBA
10/2005 - 09/2002
2CeramidesIBA
10/2005 - 09/2004
2GangliosidesIBA
10/2005 - 09/2004
2Etoposide (VP 16)FDA LinkGeneric
12/2003 - 07/2003
2Cisplatin (Platino)FDA LinkGeneric
12/2003 - 07/2003
2Reactive Oxygen Species (Oxygen Radicals)IBA
07/2003 - 09/2002
2cellular retinoic acid binding protein IIIBA
01/2002 - 01/2002
2Retinoid X Receptors (Retinoid X Receptor)IBA
01/2002 - 01/2002
1Diphosphates (Pyrophosphates)IBA
11/2021
1AlitretinoinFDA Link
02/2019
1alternariolIBA
01/2018
1methylamphotericin B (AME)IBA
01/2018
1alternariol monomethyl etherIBA
01/2018
12'-deoxyadenosineIBA
08/2016
1Dronabinol (THC)FDA LinkGeneric
06/2015
1nabiximols (Sativex)IBA
06/2015
1CannabinoidsIBA
06/2015
1CannabidiolIBA
06/2015
1Temozolomide (Temodar)FDA LinkGeneric
06/2015
1Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
08/2014
1Biomarkers (Surrogate Marker)IBA
08/2014
1Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
08/2014
1Arachidonic Acid (Vitamin F)IBA
01/2013
1Vitamin A (Retinol)FDA LinkGeneric
07/2012
1HypoxanthineIBA
03/2011
15'-methylthioadenosine phosphorylase (methylthioadenosine nucleosidase)IBA
03/2011
1X-Linked Inhibitor of Apoptosis ProteinIBA
09/2010
1ThapsigarginIBA
02/2010
1Hydrocortisone (Cortisol)FDA LinkGeneric
10/2008
1imidazoleIBA
09/2008
1Protein Disulfide-IsomerasesIBA
07/2008
1Insulin (Novolin)FDA Link
06/2008
1AntioxidantsIBA
03/2007
1Irinotecan (Camptosar)FDA LinkGeneric
02/2007
1Doxorubicin (Adriamycin)FDA LinkGeneric
02/2007
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
02/2007
1LipidsIBA
05/2006
1glucocorticoid receptor alphaIBA
05/2006
1Protein Isoforms (Isoforms)IBA
05/2006
1glucocorticoid receptor betaIBA
05/2006
1AntibodiesIBA
10/2005
1AcidsIBA
10/2005
1RyanodineIBA
08/2005
1Fura-2 (Fura 2)IBA
06/2005
1Methacholine Chloride (Methacholine)FDA Link
06/2005
1Complement System Proteins (Complement)IBA
06/2005
1ProdrugsIBA
05/2005
1p38 Mitogen-Activated Protein KinasesIBA
04/2005
1Cytochromes c (Cytochrome c)IBA
12/2004
1Desipramine (Pertofrane)FDA LinkGeneric
09/2004
1Glucosylceramides (Glucocerebrosides)IBA
09/2004
1fumonisin B1IBA
09/2004
1ceramide glucosyltransferaseIBA
09/2004
1dihydroceramide desaturaseIBA
09/2004

Therapy/Procedure

8Therapeutics
08/2016 - 12/2004
3Drug Therapy (Chemotherapy)
06/2015 - 07/2008